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. 2021 Jul 13;11:709070. doi: 10.3389/fonc.2021.709070

Table 4.

Results of subgroup analysis for evaluation of all studies.

Study characteristics No. Pooled sensitivity
(95% CI)
Pooled specificity (95% CI) Positive LR (95% CI) Negative LR (95% CI) AUC p
Total 41 0.73 (0.68-0.77) 0.74 (0.68-0.80) 2.85 (2.27-3.58) 0.36 (0.31-0.42) 0.7877
Field strength, Tesla
 1.5 28 0.72 (0.69-0.75) 0.70 (0.67-0.72) 2.04 (1.78-2.33) 0.46 (0.39-0.55) 0.7559 0.0524
 3.0 13 0.77 (0.73-0.80) 0.78 (0.75-0.81) 3.92 (2.49-6.18) 0.35 (0.27-0.46) 0.8412
High resolution
 Yes 17 0.74 (0.67-0.80) 0.78 (0.67-0.86) 3.30 (2.27-4.80) 0.34 (0.28-0.41) 0.8125 0.2513
 No/Not specified 24 0.72 (0.65-0.81) 0.73 (0.64-0.81) 2.73 (2.03-3.66) 0.37 (0.30-0.47) 0.7936
Design
 Retrospective 15 0.77 (0.73-0.81) 0.62 (0.58-0.66) 1.85 (1.53-2.22) 0.46 (0.37-0.58) 0.7421 0.1358
 Prospective 26 0.72 (0.69-0.75) 0.77 (0.75-0.79) 2.87 (2.28-3.62) 0.40 (0.33-0.49) 0.8056
Node by node
 Yes 5 0.55 (0.40-0.69) 0.89 (0.79-0.95) 5.21 (2.03-13.46) 0.51 (0.34-0.76) 0.7813 0.9405
 No 36 0.74 (0.70-0.79) 0.71 (0.64-0.77) 2.59 (2.12-3.10) 0.36 (0.31-0.42) 0.7937
Read approach
 Independent 12 0.77 (0.72-0.81) 0.64 (0.60-0.69) 2.14 (1.65-2.77) 0.42 (0.31-0.55) 0.7853 0.6774
 Consensus 29 0.73 (0.70-0.76) 0.75 (0.73-0.77) 2.53 (2.06-3.10) 0.42 (0.35-0.51) 0.7894
Blinding
 Single 7 0.72 (0.63-0.80) 0.57 (0.46-0.67) 1.70 (1.40-2.03) 0.49 (0.38-0.63) 0.7008 0.0281
 Double 34 0.73 (0.67-0.78) 0.78 (0.70-0.84) 3.31 (2.54-4.28) 0.34 (0.29-0.41) 0.8082

No., number of data subsets; AUC, area under the curve; p, p value of meta-regression analysis.