Fig. 4.

Representative proteins for each response profile. The simplified graphical representation for each protein shows the ratio for each treatment comparisons: injury (I), cytokines (C), and injury + cytokines (IC) versus control (N), and treatments with Dex versus their non-Dex controls: D vs. N, ID vs. I, CD vs. C, and ICD vs. IC. The mean fold change values from three replicates are indicated with horizontal lines. Representative proteins for the different profile categories (Table 1): (A) Group I, collagen type II (COL2A1); (B) Group II, phosphoglycerate kinase (PGK1); (C) Group III, collagenase-3 (MMP-13). Also shown are (D) connective tissue growth factor (CTGF), a representative of proteins with a consistent effect of Dex after addition to any treatment, and (E) cartilage oligomeric matrix protein (COMP), which undergoes no statistically significant change in release with any treatment.