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Pharmacokinetics and short-term in vivo evaluation of three different NPs. (A) In vivo pharmacokinetics of DiD@HOP, DiD@MHOP, and DiD@BMHOP (values represent mean ± SD, n = 3). (B) Ex vivo IVIS imaging of major organs from MCAO mice 12 h after i.v. injection of DiD@HOP, DiD@MHOP, and DiD@BMHOP. (C) Radiant efficiency of fluorescence intensity of different DiD@NPs in major organs after 12 h post-injection (values represent mean ± SD, n = 3, ***P < 0.001).
