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. 2021 Jul 6;11(16):7911–7947. doi: 10.7150/thno.56639

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Illustration of glioblastoma (GB) cell invasion at the tumor lesion rim in an orthotopic F98 GB rat model. (A) Contrast enhanced T1-weighted magnetic resonance image. Higher contrast leakage in the tumour rim and in the centre of the tumour corresponds to central tumour necrosis. (B) Hematoxylin & Eosin staining. (C) 4′,6-diamidino-2-phenylindole (DAPI) nuclear staining of another F98 GB rat brain section. (D-E-F) Tumour cells infiltrating the surrounding normal brain tissue, see arrows. (E-F) Abundant blood vessels in the perinecrotic tumour, see dashed arrows. Adapted with permission from ⁵⁰⁷, copyright 2014 Journal of Neuro-Oncology.