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. 2021 Jul 6;11(16):8076–8091. doi: 10.7150/thno.61810

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Lung infection mainly contributes to the severity of COVID-19 in SARS-CoV-2-infected K18 mice. (A) Representative H&E staining of lung sections from a K18^+/- mouse that died at 7 DPI. Left panel shows perivascular infiltration by lymphocytes, edema, hemorrhage, multifocal regions of neutrophilic inflammation; right panel shows a congested vessel. (B) Representative H&E section of cerebrum from the postmortem K18^+/- mouse at 7 DPI showing no overt pathology and mild autolytic changes. (C) H&E staining (upper panel) and corresponding immunofluorescence staining of viral spike protein (lower panel, green) in the brain of 3 K18^+/- at 7 DPI. Corresponding %weight loss changes are shown in upper panel.