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Schematic illustration of orthogonal RaST. NMs are loaded with a light-sensitive drug, TC, but directed to different cells that express VLA-4 (MM) and αvß3 (OCs) in the BM. The expression of GLUT1 on both MM and OCs provides additional selectivity for eradicating only cells that express GLUT1 and either VLA-4 or αvß3.
