Skip to main content
. 2021 Jul 6;11(16):7970–7983. doi: 10.7150/thno.62138

Figure 6.

Figure 6

Regulatory role of mdig on inflammation. A. ChIP-seq and RNA-seq of IL17RD in both WT and mdig KO cells. Red arrows point to the enhanced peaks of H3K27me3 and H3K9me3 on the IL17RD gene in mdig KO cells. B. RNA-seq shows down-regulation of these indicated inflammatory cytokine receptors or their regulatory protein in mdig KO cells. C. ChIP-seq shows increased enrichment of H3K9me3 on TLR6 gene and decreased enrichment of H3K4me3 on PTGER4 gene in mdig KO cells, which correlated to the diminished expression of these genes in RNA-seq (bottom panels). D. Enrichment of H3K27me3 and H3K9me3 on the NLRP gene loci that encode the key components of inflammasomes.