Fig 4.

(A) Representative PET/CT fusion transaxial images at 7 d and 21 d after myocardial infarction (MI) with and without co-administration of unlabeled ligand (1mg/kg). Images display the localized accumulation of [⁶⁸Ga]MHLL1 (orange) in the non-viable infarct territory defined by [¹⁸F]FDG (green) with additional distribution at the site of the surgical wound that is less prominent at 21 d after injury and limited dermal signal. (B) Reoriented cardiac axis images display the localization of the [⁶⁸Ga]MHLL1 signal (colorscale) to the infarct defined by [¹⁸F]FDG (greyscale) at both timepoints, significantly lowered by blocking. Semiquantitative analysis of percent injected dose (ID) per gram in the infarct territory and non-infarcted remote myocardium shows at (C) 7 d and (D) 21 d after coronary artery occlusion confirms the selective accumulation of [⁶⁸Ga]MHLL1 in the scar and border zone, as well as remote territory. Blocked vs. unblocked, one way analysis of variance, Bonferroni post hoc test; infarct vs. remote Students two-tailed paired t-test. Sample sizes (7 d MI n = 9, sham = 5; 21 d MI n = 6, sham n = 4).