. 2021 Jul 27;7:57. doi: 10.1038/s41421-021-00295-w

Table 3.

Summary of ten selected antibodies.

mAbs	Predicted epitope	Binding EC₅₀ (nM)		KD (nM)	Blocking IC₅₀ (nM)				Pseudovirus neutralization IC₅₀ (ng/mL)	Authentic virus PRNT IC₅₀ (ng/mL)
mAbs	Predicted epitope	S1	RBD	KD (nM)	S1	Inhibition max (%)	RBD	Inhibition max (%)	Pseudovirus neutralization IC₅₀ (ng/mL)	Authentic virus PRNT IC₅₀ (ng/mL)
3A9	RBD-2	0.038	0.042	N.D.	1.74	57	2.76	72	93	1541
1F2	RBD-1	0.068	0.048	39.4	4.34	92	2.65	98	40	25
1D10	RBD-1	0.115	0.054	N.D.	13.32	85	4.91	84	73	85
1B6	RBD-1	0.047	0.043	11.3	3.88	94	3.25	99	12	18
1H8	RBD-1	0.054	0.035	18.7	5.76	94	3.6	96	20	35
2B11	RBD-1	0.051	0.047	4.76	2.79	95	1.96	99	6	1
1D7	RBD-1	0.092	0.055	24.2	7.8	91	4.1	92	30	34
2A2	RBD-1	0.201	0.067	1070	N.A.	N.A.	4.85	93	705	1178
1E10	RBD-2	0.029	0.044	N.D.	N.A.	N.A.	N.A.	N.A.	94	21
1B10	RBD-1	0.27	0.053	N.D.	N.A.	N.A.	7.83	90	112	79

K_D dissociation constant at equilibrium, N.D. not detectable, N.A. no appreciable.

Epitope were predicted by Epitope binning via bio-layer interferometry. EC₅₀ and IC₅₀ were calculated by fitting to a four-parameter logistic curve with GraphPad Prism Version 8.0.1.