. Author manuscript; available in PMC: 2021 Jul 27.

Published in final edited form as: Tetrahedron. 2008 Feb 29;64(19):4444–4452. doi: 10.1016/j.tet.2008.02.079

Table 2.

Evaluation of the antiviral activity against human immunodeficiency virus (HIV) and cytotoxicity against PBM, CEM, and VERO cells in vitro, expressed in μM, of synthesized AZT and FLT analogues

Compound	Anti-HIV-1 activity in PBMCs (EC₅₀)	Toxicity (IC₅₀)
		PBM	CEM	VERO
AZT^a	0.016	>100	14.0	29.0
12	6.9	25.6	15.1	22.9
10a	3.1	43.0	100	82.7
10b	0.6	26.8	31.6	29.5
10c	4.9	18.4	33.1	18.5
18	2.3	19.7	31.6	14.4
16a	3.4	18.6	30.7	52.3
16b	1.1	26.2	30.6	27.7
16c	2.7	23.8	48.1	9.0

Reference compound.