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. 2021 Jul 13;12:651645. doi: 10.3389/fphys.2021.651645

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Copyright © 2021 Li, Liu, Lu, Dai, Chen and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Streptozotocin (STZ)-induced diabetic mice are more susceptible to ischemic acute kidney injury (AKI). Male C57BL/6J mice were injected with STZ or vehicle solution to induce diabetic mice (DM) or non-diabetic mice (ND). The mice were then subjected to sham operation or 30 min of bilateral renal ischemia followed by 48 h of reperfusion (I/R48). (A,B) Serum creatinine and blood urea nitrogen (BUN). (C) Hematoxylin and eosin (HE) staining for renal tissues. Scale bar, 100 μm. (D) Semi-quantification for renal tissue damage. (E) TUNEL assay to reveal apoptosis of renal tissues. Scale bar, 50 μm. (F) Statistical analysis for TUNEL-positive cells. All the data are shown as the mean ± SD (n = 6). *p < 0.05 vs. the relevant ND group.