Skip to main content
. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Hum Immunol. 2021 May 24;82(7):505–522. doi: 10.1016/j.humimm.2021.04.007

Table 4.

Probability values for Guo and Thompson Hardy-Weinberg equilibrium (HWE) tests in the UPHD populations.

Maximum allelic resolutiona
Population HLA-A HLA-C HLA-B HLA-DRB1 HLA-DRB3/4/5 HLA-DQA1 HLA-DQB1 HLA-DPA1 HLA-DPB1
European American 0.0036 0.0001 0.0000 0.0001 0.0000 0.0067 0.0014 0.0000 0.0000
African American 0.3967 0.0458 0.0004 0.0002 0.0045 0.0002 0.0010 0.0457 0.1030
USA Hispanic 0.0034 0.0011 0.0977 0.1916 0.0107 0.2181 0.0879 0.0227 0.0331
Mexican 0.2713 0.0491 0.0629 0.2286 0.0806 0.0375 0.0183 0.2912 0.1346
Spanish 0.5230 0.9906 0.1151 0.8920 0.5300 0.3015 0.7955 0.0129 0.9012
Italian 0.8447 0.0985 0.8679 0.2448 NT NT 0.1224 NT 0.0025
Greek 0.4691 0.5181 0.7447 0.3585 NT 0.1268 0.2305 NT 0.1233
Arab 0.0007 0.1866 0.1187 0.2123 0.5325 0.1640 0.1951 0.3769 0.4846
European 0.9083 0.2381 0.0852 0.0075 0.0082 0.0012 0.0068 3.0E-05 0.1332
API 0.0005 6.0E-05 0.0000 0.0003 0.0009 0.0001 0.0226 0.1848 0.2367
Thai 0.8839 0.0970 0.3526 0.2229 NT NT 0.2942 NT 0.7104
India 0.2216 0.8316 0.2299 0.4482 NT 0.4661 0.1402 0.0219 0.0197
2-Field allele resolutionb
Population HLA-A HLA-C H LA-B HLA-DRB1 HLA-DRB3/4/5 HLA-DQA1 HLA-DQB1 HLA-DPA1 HLA-DPB1
European American 0.0024 0.0053 2.0E-05 0.0001 0.0005 0.1575 0.0027 0.0007 0.0000
African American 0.5170 0.0446 0.0004 0.0003 0.0122 0.0969 0.0491 0.5912 0.1328
USA Hispanic 0.0041 0.1008 0.0511 0.1217 0.3845 0.1598 0.2138 0.3784 0.0249
Mexican 0.3126 0.0598 0.0835 0.1564 0.2390 0.0181 0.0641 0.0713 0.5244
Spanish 0.3135 0.9281 0.2699 0.8588 0.2817 0.7791 0.5180 0.1513 0.8987
Italian 0.8016 0.2731 0.6705 0.2305 NT NT 0.2882 NT 0.0004
Greek 0.3984 0.8091 0.8724 0.3815 NT 0.3061 0.1838 NT 0.0579
Arab 0.0003 0.2089 0.1479 0.1720 0.6508 0.4250 0.1559 0.7203 0.3533
European 0.7474 0.1366 0.1881 0.0039 0.5274 0.0340 0.0016 0.7028 0.1569
API 0.0005 0.0019 0.0000 0.0004 0.0624 0.0112 0.0430 0.5365 0.2509
Thai 0.8633 0.0970 0.3526 0.2229 NT NT 0.2942 NT 0.6943
Indian 0.4011 0.5449 0.6403 0.3584 NT 0.5607 0.1448 1.0000 0.0197

HLA loci that deviated significantly (P < 0.05) from HWE are shown in boldface type.

a

HWE test performed on alleles characterized at maximum (3–4-Field) allelic resolution.

b

HWE test performed on alleles characterized at 2-Field allele resolution.