Table 2.

Rate of the most common presenting symptoms in 18 pediatric serotonin syndrome cases

	Altered Mental Status						Autonomic Hyperactivity					Neuromuscular Abnormalities
	Agitation	Confusion	Psychosis	Altered LOC	HR*	BP*	Hyperthermia*	Diaphoresis	Mydriasis	N/V/D	Shivers	Hyperreflexia	Tremors	Rigidity	Myoclonus
Total Number	10	9	7	6	12	10	9	9	8	6	6	11	10	9	7
Benzick, 2001; USA					√		√				√	√	√	√
Ghanizadeh et al, 2008; Iran	√	√	√					√		√	√
Gill et al, 1999; USA	√			√	√	√	√	√	√		√	√	√	√	√
Godinho et al, 2002; UK	√	√	√		√	√		√	√	√	√	√
Grenha et al, 2013; Portugal	√	√	√		√	√	√	√				√	√	√	√
Jahr et al, 1994; USA				√											√
Kaminski et al, 1994; USA	√		√		√		√	√	√	√	√	√
Kawano et al, 2011; Japan				√			√							√
Lee & Lee, 1999; USA	√	√											√
Lee-Kelland et al, 2018; UK		√			√	√			√	√		√	√
Likasitwattanakul, 2005; Thailand				√		√	√		√			√		√
Mullins, 1999; USA					√	√		√				√	√	√
Park & Jung, 2010; Korea		√	√		√	√		√				√	√	√	√
Phan et al, 2008; USA	√	√		√	√		√	√	√			√	√	√
Pitzianti et al, 2016; Italy	√		√		√	√			√	√			√
Satoh et al, 2006; Japan	√	√			√	√	√								√
Thomas et al, 2004; USA									√						√
Türkoglu, 2015; Turkey	√	√	√	√	√	√	√	√		√	√	√	√	√	√

BP = blood pressure; HR = heart rate; LOC = level of consciousness; N/V/D = nausea/vomiting/diarrhea

^*Hyperthermia as defined by case report or by Hamilton & John, 2013; increased blood pressure (hypertension) and heart rate (tachcardia) defined by case report or by Disque, 2016