Table 1.
Non-Inflammatory State | Obesity/T2DM |
---|---|
Intra-islet macrophages and peri-islet macrophages9,13 | Increased number of intra-islet macrophages7,9,14,17,28 |
Supports islet (β cell) development and regeneration11–13 | Promotes compensatory β cell proliferation9 |
Promotes GSIS9 | Suppresses GSIS with decreased expression of β cell-specific genes7,9,49,50 |
Low concentration of IL-1β 7,13,88,91 | Elevated production of IL-1β7,40,49 |