TABLE 3.

Literature verification of the predicted obesity-related microbes.

Microbe	Literature
Unclassified Lachnospiraceae	PMID:32784721
Dialister succinatiphilus	PMID:28261164
Clostridium cluster XVIII	PMID:31281460
rc4-4	PMID:27304513
Dorea	PMID:31530820
Robinsoniella	PMID:23454028
Enterobacteriaceae	PMID:32805279

The case studies mentioned above indicate that our method is effective for prioritizing novel disease-related microbes, and the prioritized microbes may be used as biomarkers for disease prevention, diagnosis, and prognosis.