Table 4.
Multivariable associations reaching LDL-C target reduction or on appropriate therapya in DUHS.
| Characteristic | Appropriate therapy N = 1753 |
Inappropriate therapy N = 2458 |
Adjusted OR | 95% CI | P-value |
|---|---|---|---|---|---|
| Ageb | 59 (50, 67) | 59 (49, 68) | 1.01 | (0.94, 1.10) | 0.713 |
| Sex (female) | 60.6% (1063) | 66.2% (1627) | 0.69 | (0.59, 0.81) | <.001 |
| Race | 0.033 | ||||
| Caucasianc | 66.6% (1158) | 72.4% (1761) | 1.07 | (0.90, 1.28) | |
| African American | 26.4% (458) | 22.6% (549) | 1.00 | (ref) | |
| Other | 7.0% (122) | 5.1% (124) | 1.50 | (1.10, 2.03) | |
| Insurance | 0.050 | ||||
| Commercialc | 59.0% (1034) | 61.3% (1507) | 1.00 | (ref) | |
| Government | 38.4% (673) | 37.2% (914) | 1.08 | (0.89, 1.32) | |
| Other/no insurance/not specified | 2.6% (46) | 1.5% (37) | 1.89 | (1.11, 3.19) | |
| ASCVD | 10.2% (178) | 5.9% (146) | 1.22 | (0.91, 1.66) | 0.188 |
| Hypertension | 36.6% (642) | 30.4% (746) | 1.04 | (0.87, 1.24) | 0.671 |
| Diabetes | 15.9% (279) | 8.1% (198) | 2.07 | (1.62, 2.65) | <.001 |
| Provider | 0.010 | ||||
| Cardiology | 4.5% (79) | 2.3% (57) | 1.89 | (1.18, 3.01) | |
| Primary carec | 85.2% (1494) | 87.1% (2142) | 0.85 | (0.65, 1.10) | |
| Other/not specified | 10.3% (180) | 10.5% (259) | 1.00 | (ref) | |
| BMI | 29 (26, 33) | 29 (25, 33) | 1.01 | (1.00, 1.02) | 0.040 |
| Family history of MI | 17.8% (312) | 16.6% (408) | 0.99 | (0.81, 1.21) | 0.916 |
Abbreviations: ASCVD, atherosclerotic cardiovascular disease; BMI, body mass index; CI, confidence interval; DUHS, Duke University Health System; LDL-C, low-density lipoprotein cholesterol; MI, myocardial infarction; OR, odds ratio; ref, reference category.
Results from multivariable logistic regression model adjusting for all factors in the table.
We defined “appropriate therapy” as meeting any of the following criteria: 1) New initiation or intensification to a high-intensity statin within 13 months, 2) LDL-C reduction by at least 50% within 13 months, or 3) LDL-C reduction of at least 30% within 13 months in subjects already on a high-intensity statin at baseline.
Odds ratio for age is calculated per 10 year increase.
Indicates the reference category There were 3035/4211 observations used in the adjusted model due to 1176 missing values of race and/or BMI.