Table 10b.

Dutch Lipid Clinic Network diagnostic criteria for Familial Hypercholesterolemia [[181], [182], [183]].

	Points
Criteria
Family history
First-degree relative with known premature∗ coronary and vascular disease, OR	1
First-degree relative with known LDL-C level above the 95th percentile
First-degree relative with tendinous xanthomata and/or arcus cornealis, OR	2
Children aged less than 18 years with LDL-C level above the 95th percentile
Clinical history
Patient with premature∗ coronary artery disease	2
Patient with premature∗ cerebral or peripheral vascular disease	1
Physical examination
Tendinous xanthomata	6
Arcus cornealis prior to age 45 years	4
Untreated cholesterol levels mg/dL (mmol/liter)
LDL-C ​≥ ​330 ​mg/dL (≥8.5)	8
LDL-C 250–329 ​mg/dL (6.5–8.4)	5
LDL-C 190–249 ​mg/dL (5.0–6.4)	3
LDL-C 155–189 ​mg/dL (4.0–4.9)	1
DNA analysis
Functional mutation in the LDLR, apo B or PCSK9 gene	8
Diagnosis (diagnosis is based on the total number of points obtained)
Definite Familial Hypercholesterolemia	>8
Probable Familial Hypercholesterolemia	6–8
Possible Familial Hypercholesterolemia	3–5
Unlikely Familial Hypercholesterolemia	<3

LDL-C ​= ​low - density lipoprotein cholesterol.

DNA ​= ​Deoxynucleic acid.

LDL-R ​= ​low - density lipoprotein receptor.

Apo B ​= ​apolipoprotein B.

PCSK9 = Proprotein convertase subtilisin/kexin type 9.

^∗Premature coronary and vascular disease = ​< ​55 years in men; < 60 years in women.