Table 3.
IVUS parameters: plaque burden, vessel wall dimension, calcification and progression. Results expressed as mean ± SD or median (interquartile range).
| Parameter | No Risk Factors n = 165 | Risk Factors n = 492 | p-value |
|---|---|---|---|
| Percent atheroma volume (%) | |||
| Baseline | 35.7 ± 8.6 | 38.0 ± 8.8 | 0.004 |
| Follow up | 35.5 ± 8.8 | 37.9 ± 9.0 | 0.003 |
| Absolute change | −0.2 ± 2.8 | −0.1 ± 3.6 | 0.71 |
| P value for change within groups | 0.43 | 0.73 | |
| Adjusted annualized changea | −0.08 ± 0.17 | −0.02 ± 0.13 | 0.64 |
| Total atheroma volume (mm3) | |||
| Baseline | 174.7 ± 80.2 | 190.9 ± 84.2 | 0.03 |
| Follow up | 169.2 ± 82.5 | 187.1 ± 84.0 | 0.02 |
| Absolute change | −5.5 ± 23.4 | −3.8 ± 22.7 | 0.42 |
| P value for change within groups | 0.003 | <0.001 | |
| Adjusted annualized changea | −2.1 ± 1.1 | −2.0 ± 0.8 | 0.90 |
| EEM volume (mm3) | |||
| Baseline | 483.2 ± 169.6 | 500.1 ± 181.7 | 0.30 |
| Follow up | 470.4 ± 174.2 | 490.5 ± 178.9 | 0.21 |
| Absolute change | −12.8 ± 49.9 | −9.6 ± 39.7 | 0.41 |
| P value for change within groups | 0.001 | <0.001 | |
| Adjusted annualized changea | −3.9 ± 2.2 | −5.0 ± 1.5 | 0.63 |
| Lumen volume (mm3) | |||
| Baseline | 308.5 ± 109.1 | 309.2 ± 118.2 | 0.95 |
| Follow up | 301.2 ± 111.1 | 303.4 ± 116.5 | 0.83 |
| Absolute change | −7.3 ± 36.3 | −5.8 ± 33.2 | 0.63 |
| P value for change within groups | 0.01 | <0.001 | |
| Adjusted annualized changea | −2.1 ± 1.8 | −3.4 ± 1.2 | 0.40 |
| Percent of images with calcium ≥1 | |||
| Baseline | 22.2 (5.1, 38.5) | 26.5 (10.9, 45.8) | 0.025 |
| Follow up | 26.4 (4.5, 44.4) | 31.3 (13.4, 50.5) | 0.03 |
| Absolute change | 1.4 (0.0, 6.9) | 2.5 (0, 8.1) | 0.51 |
| P value for change within groups | <0.001 | <0.001 | |
| PAV | |||
| Progressors (%) | 50.9 | 45.1 | 0.20 |
| Regressors (%) | 49.1 | 54.9 | |
EEM = external elastic membrane, PAV = percent atheroma volume.
a
Adjusting for trial and respective baseline measures. Least-squares means ± standard error reported.