Table 2.

Criteria for Very High Risk Status (Adapted from Grundy et al., 2019) [13].

Major ASCVD Events
- Recent ACS (within the past 12 ​mo)
- History of MI (other than recent ACS event listed above)
- History of ischemic stroke
- Symptomatic peripheral arterial disease
High-Risk Conditions
- Age ≥65 ​y
- Heterozygous familial hypercholesterolemia
- History of prior coronary artery bypass surgery or percutaneous coronary intervention outside of the major ASCVD event(s)
- Diabetes mellitus
- Hypertension
- CKD (eGFR 15–59 ​mL/min/1.73 ​m2)
- Current smoking
- Persistently elevated LDL-C (LDL-C ≥100 ​mg/dL [≥2.6 ​mmol/L]) despite maximally tolerated statin therapy and ezetimibe
- History of congestive HF

Very high-risk status is defined as two or more major ASCVD events or one major ASCVD event and multiple high risk conditions.