Figure 14:
Simulation results with different aligned fibre structures, sensing radius R = 30μm, repulsion Frep = 0.9 × 10mg/μm · min2, cell-cell adhesion Fadh = 0.12 × 10mg/μm · min2, cell-non-fibre ECM adhesion Scl = 0.01, cell-fibre ECM adhesion ScF = 1.8 and with 30% : 70% fibres and non-fibres ECM ratios. In the first row of each panel (A-F), we present the four-fold coarsened initial oriented ECM fibre field and the purple lines represent the dividing lines between the regions with different tissue alignments. In panel (A) we plot a single result at time T = 5283 minutes, in (B) at time T = 4601 minutes and in (C) at time T = 9518. In panels (D-F) we plot the results at three different times to illustrate the evolution of the tumour, specifically, we use T = 9500, T = 15000, T = 20000 minutes, respectively. The oriented ECM fibres fields are coarsened four-fold for illustration purposes. Initial center of cell cluster position was: (A-E) (0,0), (F) (−400,−200).