Figure 6:

Simulation results with random and aligned fibres, sensing radius R = 30μm, repulsion F^rep = 0.9 × 10mg/μm · min², cell-cell adhesion F^adh = 0.12 × 10mg/μm · min², cell-non-fibre ECM adhesion S_cl = 0.01, cell-fibre ECM adhesion S_cF = 1.8 and with (A-A’) 10% : 90%, (B-B’) 20% : 80%, (C-C’) 30% : 70% fibres and non-fibres ECM ratios. In (A,B,C) the fibre orientation field is set to be random and in (A’,B’,C’) it is set to be aligned. Moreover the final simulation times are (A,B,C) T = 28 days, (A’) T = 14294 minutes, (B’) T = 10761 minutes and (C’) T = 4169 minutes. For illustrative purposes, all oriented ECM fibre fields are coarsened four-fold. Initial cell position was: (A,B,C) (0,0), (A’,B’,C’) (900,−900).