Table 3. Predictive factors for AE in ILD patients assessed using the logistic regression model.
| Variable | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Age | 1.028 (0.969–1.091) | .362 | ||
| Male | 1.091 (0.034–3.561) | .885 | ||
| Ever smokers | 0.488 (0.158–1.513) | .214 | ||
| BMI | 0.942 (0.791–1.122) | .501 | ||
| Disease duration | 1.031 (1.005–1.057) | .017 | ||
| Interstitial lung disease | ||||
| IPF | 0.489 (0.125–1.908) | .303 | ||
| CTD | 0.610 (0.144–2.592) | .503 | ||
| Radiologic pattern | ||||
| UIP | 0.115 (0.014–0.930) | .430 | ||
| Pulmonary function | ||||
| FVC | 0.995 (0.940–1.014) | .218 | ||
| DLco | 0.969 (0.934–1.006) | .104 | ||
| TLC | 1.032 (0.939–1.134) | .516 | ||
| Six-minute walk test | ||||
| Distance | 0.995 (0.989–1.001) | .084 | ||
| Baseline SpO2 | 0.738 (0.573–0.952) | .019 | 0.750 (0.568–0.991) | .043 |
| Lowest SpO2 | 0.948 (0.862–1.042) | .265 | ||
| PaO2 | 0.994 (0.969–1.019) | .628 | ||
| Baseline IL-6 | 1.018 (0.999–1.037) | .062 | ||
| *Peak IL-6 | 1.017 (1.006–1.028) | .002 | 1.014 (1.001–1.027) | .036 |
| CRP | 1.223 (1.054–1.442) | .009 | ||
| WBC | 1.000 (1.000–1.000) | .045 | ||
| LDH | 1.007 (1.000–1.013) | .049 | ||
OR: odds ratio; CI: confidence interval; BMI, body mass index; IPF, idiopathic pulmonary fibrosis; CTD, connective tissue disease-associated interstitial lung disease; UIP, usual interstitial pneumonia; FVC, forced vital capacity; DLco, diffusing capacity of the lungs for carbon monoxide; TLC, total lung capacity; SpO2, saturation of peripheral oxygen; PaO2, partial pressure of oxygen; IL-6, interleukin-6; CRP, C-reactive protein; WBC, white blood cell; LDH, lactate dehydrogenase.
*Peak IL-6 –highest serum level of IL-6 among sequentially measured IL-6 during follow-up.