Table 4.
Effect of evolocumab on plaque composition stratified by baseline hsCRP. Data presented as median (Q1,Q3) or mean ± SD.
| hsCRP |
P value | |||
|---|---|---|---|---|
| <1 mg/L [n = 46] | 1–3 mg/L [n = 70] | >3 mg/L [n = 46] | ||
| Normalized volume | ||||
| Necrotic core, mm3 | ||||
| - baseline | 8.0 (4.8,14.8) | 12.2 (3.8,19.7) | 8.3 (3.9,13.9) | 0.51 |
| - follow-up | 7.9 (3.3,14.5) | 11.0 (3.5,19.3) | 5.2 (2.3,12.0) | 0.08 |
| - nominal change | −0.43 ± 1.04 | −0.39 ± 0.85 | −2.40 ± 1.05 | 0.12 |
| - p value | 0.68 | 0.65 | 0.02 | |
| Fibrofatty, mm3 | ||||
| - baseline | 23.6 (12.9,44.5) | 20.9 (8.2,49.4) | 15.9 (6.5,28.5) | 0.21 |
| - follow-up | 19.3 (5.8,32.6) | 17.6 (5.6,38.5) | 12.2 (3.7,24.7) | 0.18 |
| - nominal change | −5.41 ± 1.74 | −3.82 ± 1.41 | −5.37 ± 1.76 | 0.71 |
| - p value | <0.01 | <0.01 | <0.01 | |
| Fibrous, mm3 | ||||
| - baseline | 20.5 (10.1,29.9) | 24.5 (10.0,39.8) | 18.9 (8.6,29.5) | 0.45 |
| - follow-up | 14.9 (7.6,25.4) | 20.2 (7.7,35.4) | 14.1 (5.5,27.0) | 0.24 |
| - nominal change | −1.08 ± 1.33 | −2.94 ± 1.09 | −4.90 ± 1.34 | 0.13 |
| - p value | 0.42 | <0.01 | <0.001 | |
| Dense calcium, mm3 | ||||
| - baseline | 1.7 (0.5,6.2) | 2.6 (0.3,6.2) | 2.1 (0.8,5.1) | 0.94 |
| - follow-up | 2.3 (0.6,7.6) | 4.1 (0.5,7.0) | 1.6 (0.5,5.0) | 0.36 |
| - nominal change | 1.04 ± 0.60 | 1.45 ± 0.48 | 0.17 ± 0.60 | 0.26 |
| - p value | 0.08 | <0.01 | 0.78 | |
| Percent plaque | ||||
| Necrotic core, % | ||||
| - baseline | 14.5 (10.5,21.9) | 16.5 (11.5,20.8) | 17.9 (12.6,22.0) | 0.44 |
| - follow-up | 17.5 (10.3,21.8) | 17.8 (11.6,24.4) | 16.5 (8.3,21.8) | 0.38 |
| - nominal change | 0.11 ± 1.06 | 2.19 ± 0.88 | −0.94 ± 1.08 | 0.07 |
| - p value | 0.914 | 0.01 | 0.38 | |
| Fibrofatty, % | ||||
| - baseline | 44.5 (33.6,53.4) | 38.2 (28.1,49.4) | 35.7 (24.3,42.2) | 0.03 |
| - follow-up | 40.3 (23.7,57.5) | 34.9 (25.1,49.0) | 37.2 (25.1,44.1) | 0.52 |
| - nominal change | −0.85 ± 2.25 | −2.52 ± 1.84 | 0.58 ± 2.27 | 0.56 |
| - p value | 0.71 | 0.17 | 0.80 | |
| Fibrous, % | ||||
| - baseline | 33.6 (28.0,41.2) | 39.2 (31.5, 45.9) | 38.9 (33.9,47.5) | 0.03 |
| - follow-up | 34.7 (27.3,42.0) | 34.9 (42.0, 43.5) | 38.3 (29.8, 47.6) | 0.22 |
| - nominal change | −2.13 ± 1.47 | −2.01 ± 1.20 | −0.75 ± 1.47 | 0.76 |
| - p value | 0.15 | 0.10 | 0.61 | |
| Dense calcium, % | ||||
| - baseline | 3.5 (1.2,8.7) | 5.0 (1.4,8.3) | 4.8 (1.8,8.9) | 0.67 |
| - follow-up | 5.6 (1.2,12.3) | 6.7 (2.1,11.8) | 5.5 (2.9,10.5) | 0.77 |
| - nominal change | 2.26 ± 0.74 | 2.62 ± 0.61 | 1.31 ± 0.75 | 0.40 |
| - p value | <0.01 | <0.001 | 0.08 | |