Skip to main content
. Author manuscript; available in PMC: 2021 Jul 27.
Published in final edited form as: Wiley Interdiscip Rev Comput Mol Sci. 2020 Oct 26;11(3):e1503. doi: 10.1002/wcms.1503

FIGURE 5.

FIGURE 5

Interdependent dynamics of HNH and the REC2–3 regions. (a) Matrices of the generalized correlations (GC, upper triangle) and of the per-domain correlation score (Csi) (bottom triangle) computed for the activated state of CRISPR-Cas9 identified by MD. The strength of the correlated motions is color coded green (highly correlated motions) to gray (not correlated). (b) The highest per-domain coupled motions, involving HNH and the Rec2–3 regions, are reported using double-headed arrows.17 Reprinted with permission from Reference 17 Copyright 2018 Cambridge University Press. https://doi.org/10.1017/S0033583518000070