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Decreased gene expression of chitotriosidase mRNA was measured after stimulation of THP-1 cells with zymosan and inhibitory antibodies for Dec 206 (a), TLR-2 (b), or dectin-1 receptors (c). After addition of Dec 205, SIGN, or SIGN-related receptor antibodies, there was no inhibition of chitinase gene expression detected. Data are SEM, n = 3. THP-1, human monocyte cell line.
