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. Author manuscript; available in PMC: 2021 Oct 19.
Published in final edited form as: ACS Appl Bio Mater. 2020 Sep 17;3(10):6944–6958. doi: 10.1021/acsabm.0c00823

Figure 1. Overview of approach.

Figure 1.

(A) Hydrogels were formed in the presence of PANG, a model monoclonal antibody, and subsequently degraded by irradiation with cytocompatible doses of long-wavelength UV (365 nm) or blue light (400-500 nm) to release an encapsulated bioactive antibody. (B) Hydrogels were fonned using biologically orthogonal strain promoted azide-alkyne cycloaddition (SPAAC) click reactions. (C) Nitrobenzyl or (D) coumarin groups synthesized using scalable synthetic approaches (Scheme 1 and Scheme 2) were incorporated as crosslinks within the hydrogel network to impart light-responsive properties.