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. 2021 Jun 23;41(7):e00526-20. doi: 10.1128/MCB.00526-20

FIG 5.

FIG 5

Expression of genes downregulated in the Rp58 mutant neurons is inversely correlated to glioma progression, mesenchymal subtype acquisition, and prognosis. (A, C, E) Box plots showing the normalized expression of DLG2 (A), JAKMIP1(C), and TOX (E) genes in human glioma samples according to tumor grade and following analysis of the RNA expression results from TCGA GBM-LGG samples using GlioVis (n = 226 grade II, n = 244 grade III, and n = 150 grade IV or GBMs). (B, D, F) Box plots showing the normalized expression of DLG2 (B), JAKMIP1(D), and TOX (F) genes in GBM samples according to tumor subtype following analysis of the RNA expression results from GBM TCGA samples using GlioVis (n = 163 subtype P [proneural], n = 199 subtype C [classical], and n = 166 subtype M [mesenchymal]). (A, B, C, D, E, F) ***, P < 0.001. (G) Kaplan-Meier survival curves of TCGA GBM patients using GlioVis showing that the low level of TOX expression correlates with worse overall survival (P value calculated using the log rank test; high versus low expression). Number of samples used is indicated.