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. 2021 Jul 23;14:3261–3276. doi: 10.2147/JIR.S316314

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© 2021 Li et al.

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Neuroprotective effects of DZF on dopaminergic neurons in MPTP-induced parkinsonian mice. (A) The schematic diagram of animal modeling and administration experiment. DZF significantly resulted protected from MPTP induced reductions in (B) DA, but is insensitive to its metabolite (C) DOPAC and (D) HVA. DZF improves MPTP-induced locomotor activity dysfunction including (E) pole, (F) rotarod, (G) grip, and (H) traction test. (I) Immunohistostaining for TH (dopaminergic neuron marker) in the SNpc. (J) Quantitative analysis of the number of TH-positive cells in the SNpc. (K) Representative Western blot of midbrain TH expression. (L) The intensity of bands was quantified with Image J software and quantitative data for TH following normalization to β-actin. Data represent the means ± SEM; Statistics one-way ANOVA; ^##P < 0.01, ^###P < 0.001 vs Control group; *P < 0.05, **P < 0.01, ***P < 0.001, vs MPTP group; ^&&&P < 0.001 vs MPTP-DZF group, n = 10 for behavioral test and HPLC analysis. n = 3 for immunohistochemical and Western blotting.