Appendix 3—figure 1. Effect of permuting the weights in the re-weighted (data-tilting) GWAS.

Here we show the results of 20 random permutations of the weights, applied to the Kenyan case-control GWAS using only chromosomes 4, 9 and 11 (where the top hits are – we limit it to these three chromosomes for computational reasons). The random permutations (grey) decrease the number of significant hits compared to the non-weighted (thick black) and the non-permuted re-weighted model (dashed purple).