Appendix 6—figure 1. Distribution of admission haemoglobin concentrations as a function of P(Severe malaria | Data).

Severe anaemia is generally defined as a haemoglobin less than 5 g/dL in African children diagnosed with severe malaria, shown by the horizontal dashed red line in the top panel and the vertical dashed red lines in the bottom panels. The vertical dashed red lines in the top panel show the top and bottom quintiles of the probability distribution (0.9 and 0.2, respectively). Patients in the bottom quintile of the probability distribution had a markedly bimodal distribution in haemoglobin concentrations with a substantial proportion meeting the severe anaemia criterion and a substantial proportion with relatively high haemoglobin concentrations (>10 g/dL), suggesting two patients subgroups. Patients in the top quintile had a unimodal distribution of haemoglobin.