Table 3.
Effect of Vernonia auriculifera Crude Extract on Excision Wound Area in mm2 in Mice
| Days | Negative Control | 5% w/w Vernonia auriculifera Hiern | 10% w/w Vernonia auriculifera Hiern | Positive Control |
|---|---|---|---|---|
| Wound area in mm2 ± SEM (% contraction) | ||||
| 2 | 262.67±1.36 (12.66) | 238.17±1.62A3C3D3 (20.66) | 224.33±1.09A3B3 (25.33) | 219.17±1.08A3B3 (26.75) |
| 4 | 231± 0.81 (23.00) | 200±0.51A3C3D3 (31.64) | 182± 0.36A3B3D2 (39.33) | 177±1.30A3B3C2 (40.76) |
| 6 | 213± 0.72 (29.00) | 169 ± 0.63A3C3D3 (43.66) | 136±0.51A3B3 (54.45) | 134±0.63A3B3 (55.09) |
| 8 | 175±0.51 (41.66) | 126 ±0.36A3C3D3 (58.00) | 91± 0.36A3B3D1 (69.42) | 89±0.51A3B3C1 (70.06) |
| 10 | 155 ± 0.77 (45.94) | 104±0.51A3C3D3 (65.28) | 64.67±0.66A3B3 (78.02) | 64± 0.68A3B3 (78.66) |
| 12 | 131± 0.36 (53.33) | 72.00± 0.51A3C3D3 (76.0) | 36.83±0.65A3B3 (87.57) | 36±0.57A3B3 (87.89) |
| 14 | 98.5 ± 0.88 (64.01) | 38.83 ±0.47A3C3D3 (86.94) | 21±0.36A3B3 (93.00) | 20±0.36A3B3 (93.31) |
| 16 | 70.17±0.47 (76.61) | 20.83±0.30A3C3D3 (93.05) | 5.67±0.33A3B3 (98.11) | 4.83±0.40A3B3 (98.38) |
| 18 | 5.83±0.30 (98.05) | 5.83±0.30A3C3D3 (98.05) | 0.00±0.00A3B3 (100) | 0.00± 0.00A3B3 (100) |
| EPD | 21.17 ± 0.60 | 19.17 ± 0.91A3 | 17.83 ± 0.60A1 | 17.67 ± 0.42A2 |
Notes: Values are expressed as Mean ± SEM, values in parenthesis indicate % wound contraction; n = 6; ACompared to the negative control, BCompared to the 5% w/w crude extract, CCompared to the 10% w/w crude extract, DCompared to the positive control; 1= P < 0.05, 2= P < 0.01, 3= P < 0.001.
Abbreviation: EPD, Epithelialization Days.