. 2021 Jul 23;13:677–692. doi: 10.2147/JEP.S308303

Table 7.

Effect of Vernonia auriculifera Hiern Crude Extract on Burn Wound Model in Mice

Days	Simple Ointment	5% w/w Vernonia auriculifera Hiern	10% w/w Vernonia auriculifera Hiern	SSD 1% Ointment
	Wound area in mm ² (mean± ME) and Percentage of wound contraction
2	234 ± 0.30	234 ± 0.40	234 ± 0.49^A***	234 ± 0.48^A***
2	(21.97)	(21.97)	(21.97)	(21.97)
4	189 ± 0.44	139 ± 0.30	103 ± 0.30^A***	104±0.60^A***
4	(37)	(53.66)	(65.66)	(65.33)
6	154±0.36	105± 0.40^A*	68±0.36^A***	70± 0.30^A***
6	(48.66)	(64.97)	(77.33)	(76.66)
8	116± 0.51	74 ± 0.40^A*	37±0.36^A***	36±0.36^A***
8	(61.33)	(75.15)	(87.66)	(88.00)
10	77 ± 0.47	47± 0.25^A*	21.00±0.3^A***	9.±0.30^A***
10	(74.33)	(84.07)	(93.00)	(97.00)
12	35.83 ± 0.47	24 ± 0.36^A*	10±0.36^A***	9±0.30^A***
12	(88.05)	(91.74)	(96.7)	(97.00)
14	35.83±0.47	9.67±0.66^A**	2.83±0.30^A***	1.83±0.30^A***
14	(88.05)	(96.77)	(99.05)	(99.38)
16	17.83±0.30	2.5±0.22^A**	0.00±0.00^A***	0.00±0.00^A***
16	(94.05)	(99.16)	(100.00)	(100.00)
EPD	19.16	16.67^A*	14.5^A***	14.33^A***

Notes: Values are expressed as Mean ± SEM, values in parenthesis indicate % wound contraction; n = 6; ^A=compared to the negative control, *P < 0.05, **P < 0.01, ***P < 0.001; Initial wound area was 300 mm2.

Abbreviations: EPD, epithelialization Days; SSD, silver sulfadiazine ointment.