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High glucose increases the protein levels of TGF-β1, FN, and collagen I through the phosphorylation of the JAK2/STAT3 pathway (n = 3). (a, b) High glucose facilitated the phosphorylation of JAK2 and STAT3. (c, d) AG490 (100 μM) inhibited JAK2/STAT3 phosphorylation and (e) reduced the overexpression of TGF-β1, FN, and collagen I proteins (∗P < 0.05 compared with the NC group; †P < 0.05 compared with the HG25 group).
