Table 3.
Changes of IMA in neurological disorders.
| Pathology | Age, years | No. enrolled, method | IMA value | Reference | |
|---|---|---|---|---|---|
| Control | Patients | ||||
| Acute ischemic stroke | 55-56 | n = 50, ACB | 70.71 ± 8.42 U/mL 79 ± 6.3 IU/L 44.47 ± 5.28 U/mL |
97.56 ± 13.74 U/mL 108 ± 8.9 IU/L 96.83 ± 12.01 U/mL |
[95] [54] [98] |
|
| |||||
| Alzheimer's disease | 79.68 ± 7.58 | n = 38, ELISA | 409.59 ± 66.35 ng/mL | 609.17 ± 327.61 ng/mL | [99] |
|
| |||||
| Depression | 39.4 | n = 59, ACB | 0.73-0.90 ABSU | 0.66–0.92 ABSU | [100] |
|
| |||||
| Schizophrenia | 33.61 ± 10.02 | n = 28, ACB | 0.44 ± 0.09 ABSU | 0.53 ± 0.15 ABSU | [101] |
|
| |||||
| Bipolar disorder (BD) | 33.34 ± 1.13 | n = 32, ACB | 0.44 ± 0.09 ABSU | 0.54 ± 0.16 ABSU | [101] |
|
| |||||
| BD in remission | 38.2 ± 7.5 | n = 35 | 0.546 ± 0.13 ABSU | 0.532 ± 0.14 ABSU | [102] |
|
| |||||
| Neonatal hypoxic-ischemic encephalopathy (HIE) | Neonates∗ |
n = 60, ELISA n = 18 n = 30 n = 12 |
120.24 ± 38.9 pmol/mL | 250.83 ± 36.07 pmol/mL 207.3 ± 26.65 pmol/mL (mild), 259.28 ± 11.68 pmol/mL (moderate), 294.99 ± 4.41 pmol/mL (severe degree) |
[103] |
∗IMA levels in cord blood.