TABLE 1.
MICs of imipenem and meropenem and results of the rapid ResaImipenem/Acinetobacter NP test for the tested A. baumannii isolatesa
| Isolate | Resistance determinant(s) | Geographical origin | Imipenem phenotype | BMD MIC range (μg/ml) |
Rapid ResaImipenem/Acinetobacter NP test |
||
|---|---|---|---|---|---|---|---|
| Imipenem | Meropenem | Result | Discrepancy with MIC imipenem result | ||||
| R109 | WTb | France | S | 0.125 | 0.5 | Susceptible | No |
| R112 | WT | France | S | 0.125 | 0.25 | Susceptible | No |
| R1325 | WT | Poland | S | 0.25 | 0.5 | Susceptible | No |
| R1386 | WT | France | S | 0.125 | 0.25 | Susceptible | No |
| R1387 | WT | France | S | 0.125 | 0.5 | Susceptible | No |
| R1388 | WT | France | S | 0.25 | 0.5 | Susceptible | No |
| R1389 | WT | France | S | 0.125 | 0.5 | Susceptible | No |
| R1390 | WT | France | S | 0.125 | 0.25 | Susceptible | No |
| R1391 | WT | France | S | 0.125 | 0.25 | Susceptible | No |
| R1392 | WT | France | S | 0.5 | 0.5 | Susceptible | No |
| R1393 | WT | France | S | 0.125 | 0.5 | Susceptible | No |
| R1394 | WT | France | S | 0.125 | 0.125 | Susceptible | No |
| R1395 | WT | France | S | 0.125 | 0.125 | Susceptible | No |
| R1396 | WT | France | S | 0.125 | 0.5 | Susceptible | No |
| R1397 | WT | Bahrain | S | 0.125 | 0.25 | Susceptible | No |
| R1402 | WT | France | S | 0.5 | 0.5 | Susceptible | No |
| R2201 | WT | France | S | 0.125 | 0.125 | Susceptible | No |
| R2513 | WT | Hong Kong | S | 0.125 | 0.125 | Susceptible | No |
| R2464 | WT | France | S | 0.25 | 0.25 | Susceptible | No |
| R2270 | WT | France | S | 0.125 | 0.125 | Susceptible | No |
| N710 | WT | Switzerland | S | 0.5 | 0.5 | Susceptible | No |
| N862 | WT | Switzerland | S | 0.25 | 0.5 | Susceptible | No |
| N891 | WT | Switzerland | S | 1 | 0.5 | Susceptible | No |
| N982 | WT | Switzerland | S | 1 | 1 | Susceptible | No |
| R1322 | OXA-51 overproduced (ISAba1-blaOXA-51) | France | S | 2 | 2 | Susceptible | No |
| R1323 | OXA-51 overproduced (ISAba1-blaOXA-51) | France | S | 2 | 2 | Susceptible | No |
| N25 | OXA-51 overproduced (ISAba1-blaOXA-51) | Switzerland | S | 2 | 8 | Susceptible | No |
| R5 | OXA-51 overproduced (ISAba1-blaOXA-51) | France | S | 2 | 2 | Susceptible | No |
| R820 | OXA-51 overproduced (ISAba1-blaOXA-51) | Bahrein | S | 2 | 2 | Susceptible | No |
| N58 | OXA-51 overproduced (ISAba1-blaOXA-51) | Switzerland | S | 2 | 8 | Susceptible | No |
| R854 | OXA-51-like overproduced (ISAba9-blaOXA-51) | Greece | S | 1 | 2 | Susceptible | No |
| R1398 | AmpC overproduced (ISAba1-blaampC) | France | S | 2 | 2 | Susceptible | No |
| R1399 | AmpC overproduced (ISAba1-blaampC) | France | S | 2 | 2 | Susceptible | No |
| R1400 | AmpC overproduced (ISAba1-blaampC) | France | S | 1 | 2 | Susceptible | No |
| R1401 | AmpC overproduced (ISAba1-blaampC) | France | S | 2 | 2 | Susceptible | No |
| R150 | CTX-M-15 | France | S | 0.125 | 0.5 | Susceptible | No |
| R1139 | PER-1 | Turkey | S | 0.25 | 1 | Susceptible | No |
| R1149 | VEB-1a | Argentina | S | 0.25 | 0.5 | Susceptible | No |
| R1150 | VEB-1a | Argentina | S | 0.25 | 0.25 | Susceptible | No |
| R1151 | VEB-1a | Argentina | S | 0.25 | 0.5 | Susceptible | No |
| R1152 | VEB-1a | Argentina | S | 0.25 | 0.5 | Susceptible | No |
| R152 | VEB-1 | France | S | 0.5 | 0.5 | Susceptible | No |
| R1144 | VEB-1 | France | S | 0.25 | 0.5 | Susceptible | No |
| R1145 | VEB-1 + OXA-51 overproduced (ISAba1-blaOXA-51) | France | S | 0.5 | 0.5 | Susceptible | No |
| R1146 | VEB-1 + OXA-51 overproduced (ISAba1-blaOXA-51) | France | S | 0.5 | 1 | Susceptible | No |
| R1147 | VEB-1 + OXA-51 overproduced (ISAba1-blaOXA-51) | France | S | 2 | 1 | Susceptible | No |
| R1148 | VEB-1 + OXA-51 overproduced (ISAba1-blaOXA-51) | France | S | 1 | 2 | Susceptible | No |
| R1259 | ESAC | France | S | 0.5 | 0.5 | Susceptible | No |
| R1141 | RTG-4 (CARB10) | France | S | 0.25 | 0.5 | Susceptible | No |
| R1143 | GES-12 | France | R | 32 | >32 | Resistant | No |
| R187 | GES-14 | France | R | 32 | 32 | Resistant | No |
| R71 | IMP-4 | France | R | 16 | >32 | Resistant | No |
| R176 | NDM-1 | France | R | 32 | >32 | Resistant | No |
| R35 | NDM-1 | France | R | 32 | 32 | Resistant | No |
| R41 | NDM-1 | France | R | 16 | >32 | Resistant | No |
| R43 | NDM-1 | France | R | 16 | 32 | Resistant | No |
| R3392 | NDM-1 | France | R | >32 | >32 | Resistant | No |
| R27 | NDM-2 | France | R | 16 | 16 | Resistant | No |
| N739 | NDM-5 | Switzerland | R | >32 | >32 | Resistant | No |
| R16 | OXA-143 | France | R | 32 | >32 | Resistant | No |
| R1324 | OXA-23 | Poland | R | 16 | 16 | Resistant | No |
| R2512 | OXA-23 | France | R | 16 | >32 | Resistant | No |
| R3382 | OXA-23 | Turkey | R | 32 | >32 | Resistant | No |
| R3383 | OXA-23 | Turkey | R | >32 | >32 | Resistant | No |
| R3384 | OXA-23 | Turkey | R | >32 | >32 | Resistant | No |
| R3385 | OXA-23 | Turkey | R | >32 | >32 | Resistant | No |
| R3386 | OXA-23 | Turkey | R | >32 | >32 | Resistant | No |
| R3387 | OXA-23 | Turkey | R | >32 | >32 | Resistant | No |
| R3388 | OXA-23 | France | R | >32 | >32 | Resistant | No |
| R3389 | OXA-23 | Switzerland | R | >32 | >32 | Resistant | No |
| R3390 | OXA-23 | Switzerland | R | >32 | >32 | Resistant | No |
| R637 | OXA-23 | France | R | >32 | >32 | Resistant | No |
| R639 | OXA-23 | France | R | 16 | 16 | Resistant | No |
| R669 | OXA-23 | France | R | >32 | >32 | Resistant | No |
| R670 | OXA-23 | France | R | >32 | >32 | Resistant | No |
| R676 | OXA-23 | France | R | 32 | >32 | Resistant | No |
| R622 | OXA-23 | France | R | >32 | >32 | Resistant | No |
| R623 | OXA-23 | Saudi Arabia | R | >32 | >32 | Resistant | No |
| R624 | OXA-23 | Colombia | R | >32 | >32 | Resistant | No |
| R625 | OXA-23 | France | R | >32 | >32 | Resistant | No |
| R626 | OXA-23 | Bahrein | R | >32 | >32 | Resistant | No |
| R695 | OXA-24 | France | R | >32 | >32 | Resistant | No |
| R696 | OXA-24 | France | R | >32 | >32 | Resistant | No |
| R697 | OXA-25 | France | R | 16 | 16 | Resistant | No |
| R698 | OXA-25 | Spain | R | >32 | >32 | Resistant | No |
| R699 | OXA-26 | France | R | 32 | 32 | Resistant | No |
| R700 | OXA-26 | Belgium | R | >32 | >32 | Resistant | No |
| R701 | OXA-27 | France | R | 8 | 16 | Resistant | No |
| R3391 | OXA-40 | Switzerland | R | 32 | >32 | Resistant | No |
| R3393 | OXA-40 | Italy | R | >32 | >32 | Resistant | No |
| R3397 | OXA-40 | Switzerland | R | >32 | >32 | Resistant | No |
| R703 | OXA-40 | France | R | >32 | >32 | Resistant | No |
| R704 | OXA-40 | France | R | >32 | >32 | Resistant | No |
| N14 | OXA-40 | Switzerland | R | >32 | >32 | Resistant | No |
| N774 | OXA-40 | Switzerland | R | >32 | >32 | Resistant | No |
| R215 | OXA-40 | France | R | >32 | >32 | Resistant | No |
| R14 | OXA-40 | France | R | >32 | >32 | Resistant | No |
| R3398 | OXA-51 overproduced (ISAba1-blaOXA-51) | France | R | 6 | 4 | Resistant | No |
| R817 | OXA-51 overproduced (ISAba1- + ISAba9-blaOXA-51) | Greece | R | 8 | 3 | Resistant | No |
| R1142 | SHV-5 + OXA-51 overproduced (ISAba1-blaOXA-51) | France | R | 16 | 16 | Resistant | No |
| N211 | OXA-51 overproduced (ISAba1-blaOXA-51) + impermeability + efflux pump | Switzerland | R | 8 | 6 | Resistant | No |
| N671 | OXA-51 overproduced (ISAba1-blaOXA-51) + impermeability + efflux pump | Switzerland | R | 6 | 16 | Resistant | No |
| R842 | OXA-58 | France | R | 32 | >32 | Resistant | No |
| R843 | OXA-58 | France | R | >32 | >32 | Resistant | No |
| R845 | OXA-58 | France | R | 16 | 32 | Resistant | No |
| R857 | OXA-72 | France | R | >32 | >32 | Resistant | No |
| R858 | OXA-72 | Bahrain | R | >32 | >32 | Resistant | No |
| R859 | OXA-72 | Bahrain | R | >32 | >32 | Resistant | No |
| R860 | OXA-72 | Bahrain | R | >32 | >32 | Resistant | No |
| R3 | OXA-97 (OXA-58-like) | France | R | 32 | >32 | Resistant | No |
a
S, susceptible; R, resistant; BMD, broth microdilution; WT, wild type; ESAC, extended-spectrum AmpC. The results for strains with MIC values of imipenem of 6 mg/liter were obtained after 3 h of incubation.
b
Nonoverexpressed OXA-51-like β-lactamases are naturally occurring and chromosome-borne carbapenemases in A. baumannii.