TABLE 1.
Median (range) MLN drug concentrations quantified by LC-MS/MS and MSI
| Drug |
n (n BLQa) |
LC-MS/MS concn (ng/g of tissue) |
MSI concn (ng/g of tissue) |
r | P |
|---|---|---|---|---|---|
| FTC | 17 (11) | 55 (10–135) | BLQ (BLQ–348) | 0.24 | 0.35 |
| TFV | 17 (3) | 1,477 (109–7,140) | 520 (BLQ–2,741) | 0.64 | 0.006 |
| EFV | 8 (0) | 157 (43–1,231)b | 152 (15–2,457)b | 0.62 | 0.11 |
| RAL | 8 (7) | 20 (11–62) | BLQ (BLQ–71) | 0.74 | 0.03 |
| MVC | 9 (0) | 4,792 (1,054–14,622) | 7,439 (1,221–39,711) | 0.75 | 0.02 |
| ATV | 9 (3) | 12 (1.7–784)b | 50 (12–825)b | 0.90 | 0.001 |
a
BLQ, below limit of quantitation.
b
Protein binding adjusted; Pearson correlation test.