TABLE 2.

MLN area covered by raw and heme-corrected drug response and heme-corrected drug response at concentrations greater than the IC₅₀^a

Drug	n (n BLQ)	Median (range) % of MLN area covered by ARV			Median (range) % of heme-corrected ARV area >IC50 (BLQs excluded)	IC50 value (ng/g of tissue)	IC50 reference
		Raw	Heme corrected	P
FTC	17 (11)	1.6 (0.09–11)	1.6 (0.07–11)	NS	100 (95–100)	149	35
TFV	17 (3)	8.4 (0.1–71)	7.8 (0.1–71)	NS	97 (23–100)	2,303	34
EFV	8 (0)	22 (5.2–77)	22 (4.9–76)	NS	100 (100–100)	11.9b	41
RAL	8 (7)	0.10 (0.03–0.42)	0.08 (0.03–0.42)	NS	100 (100–100)	2.9	42
MVC	9 (0)	79 (56–97)	79 (55–96)	NS	100 (100–100)	2.2	43
ATV	9 (3)	3.3 (1.2–97)	3.2 (1–96)	NS	100 (100–100)	16.6b	44
Cumulative	17	70 (5.8–99)	69 (5.4–98)	NS

^aMann-Whitney rank sum test. NS, not significant.

^bProtein binding adjusted.