TABLE 1.

Lineage and genotypic resistance to first- and second-line drugs for PZA-monoresistant clinical isolates^a

Isolate	Phylogenetic typing		Mutationb
			INH		RIF	FQ		SLIDs
	Lineagec	Spoligotypingd	katG	fabG1p	rpoB	gyrA	gyrB	rrs
SEA12126	IO	EAI5 (SIT 1082)	Arg463Leu	WT	Synonymous	Glu21Gln, Ser95Thr, Ala384Val, Gly668Asp	Ala130Ser, Met291Ile	WT
SEA12334	IO	EAI6_BGD1 (SIT 43)	Arg463Leu	WT	Synonymous	Glu21Gln, Ser95Thr, Ala384Val, Gly668Asp	Met291Ile	WT
SEA13111	IO	EAI3-IND (SIT 414)	Arg463Leu	WT	Synonymous	Glu21Gln, Ser95Thr, Ala384Val, Gly668Asp	Met291Ile	WT
SEA12202	IO	NA	Arg463Leu	WT	Synonymous	Glu21Gln, Ser95Thr, Ala384Val, Gly668Asp	Met291Ile	WT
SEA00042	EAM	NA	WT	WT	Synonymous	Glu21Gln, Ser95Thr, Gly668Asp	WT	WT
SEA06535	EAM	U (SIT 1142)	WT	WT	Synonymous	Glu21Gln, Ser95Thr, Gly668Asp	WT	WT
SEA08151	IO	EAI1_SOM (SIT 48)	Arg463Leu	WT	Synonymous	Glu21Gln, Ser95Thr, Ala384Val, Gly668Asp	Met291Ile	G883A
SEA08162	EAM	LAM4 (SIT 1530)	WT	WT	Glu21Gln, Ser95Thr, Gly247Ser, Gly668Asp	WT	WT
SEA10007	IO	EAI1_SOM (SIT 48)	Arg463Leu	WT	Synonymous	Glu21Gln, Ser95Thr, Ala384Val, Gly668Asp	Met291Ile	G883A
SEA11278	Ethiopian	SIT 910	Arg463Leu	WT	Synonymous	Glu21Gln, Ser95Thr, Gly668Asp	WT	WT
SEA14117	EAS	Beijing-like (SIT 269)	Arg463Leu	WT	Synonymous	Glu21Gln, Ser95Thr, Gly668Asp	WT	WT
SEA14318	IO	EAI5 (SIT 138)	Arg463Leu	WT	Synonymous	Ser95Thr, Glu214Asp, Ala384Val, Gly668Asp	Met291Ile	WT
SEA15209	M. canettii	NA	Arg463Leu	C-183G	Synonymous	Glu21Gln, Ser95Thr, Asp504Glu, Gly668Asp, -ATCAGGCTC2518	WT	T6G
SEA10470	EAM	H3 (SIT 50)	WT	WT	Synonymous	Glu21Gln, Ser95Thr, Gly668Asp	WT	WT
SEA09167	EAM	LAM11_ZWE (SIT 59)	WT	WT	WT	Glu21Gln, Ser95Thr, Gly668Asp	Val301Leu	WT
SEA14333	IO	EAI1-SOM (SIT 735)	Arg463Leu	WT	Synonymous	Glu21Gln, Ser95Thr, Ala384Val, Gly668Asp	Met291Ile	G1454C
SEA15228	IO	EAI1-SOM (SIT 48)	Arg463Leu	WT	Synonymous	Glu21Gln, Ser95Thr, Ala384Val, Gly668Asp	Met291Ile	WT
SEA15229	IO	EAI3-IND (SIT 11)	Arg463Leu	WT	Synonymous	Glu21Gln, Ser95Thr, Ala384Val, Gly668Asp	Met291Ile	WT
SEA15230	IO	EAI5 (SIT 299)	Arg463Leu	WT	Synonymous	Glu21Gln, Ser95Thr, Ala384Val, Gly668Asp	Met291Ile	WT

^aIsolates were collected from TB patients in Sweden between 2000 and 2015.

^bMutations in known resistance genes. Genes with a wild-type allele (WT) are those matching reference and virulent type strain H37Rv. INH, isoniazid; RIF, rifampin; FQ, fluoroquinolones; SLIDs, second-line injectable drugs.

^cDefined according to large sequence polymorphism classification (34). IO, Indo-Oceanic; EAM, Euro-American; EAS, East Asian.

^dNA, not available (spoligotyping data unavailable).