FIG 3.

Clinical scores recorded throughout the study. Mice were challenged with a mean retained dose of 272 CFU of F. tularensis by the inhalational route and treated with finafloxacin (23.1 mg/kg) every 8 h by the oral route or ciprofloxacin (30 mg/kg) every 12 h by the i.p. route. Control animals received substances by the oral (vehicle) or i.p. (PBS) route. Regimens were initiated at 24 or 72 h postchallenge and continued for 3 or 7 days. These are heat maps for each mouse in the study, determined using the clinical scores recorded for each individual mouse, a minimum of twice daily. The lighter the color, the less severe the disease. Gray boxes represent animals that succumbed to infection. The arrows and shaded boxes represent the treatment period.