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. 2021 Jul 13;11:616372. doi: 10.3389/fonc.2021.616372

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Copyright © 2021 Zhang, Zhu, Sun, Qin, Zhang, Feng, Yan and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The tumor growth might be suppressed by miR-30b-5p or miR-30e-5p. (A) Injection protocols of the miR-30b-5p or miR-30e-5p for subcutaneous tumorigenesis in nude mice. (B) Macro images of subcutaneous tumors. (C, E) The volume of subcutaneous tumors in nude mice. (D, F) The body weight of tumorigenesis nude mice. (G) Representative images of H&E staining of subcutaneous tumors injected with different miRNAs (400×). (H, I) The expression of KRAS or Ki67 in subcutaneous injected with different miRNAs (400×). (**p<0.01, ***p<0.001).