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. 2021 Jul 28;142:111954. doi: 10.1016/j.biopha.2021.111954

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — SAveRUNNER. A) The network-based algorithm used to identify off-label drug indications against COVID-19 [40]. B) The SAveRUNNER outcome network showing the high-confidence predicted drug-disease associations (p-value ≤ 0.05) connecting COVID-19 with 399 FDA-approved non-COVID-19 drugs. Drugs are colored according to the targeted pathways reported in the legend.