Fig. 3.

Random Walk with Restart (RWR). A) Sketch of the RWR algorithm applied on the human interactome. Red nodes represent the starting point nodes, light blue nodes represent all visited nodes at the end of the algorithm run, and black nodes represent the nodes of the human interactome that were not visited. B) Distribution of modified z-score-normalized probabilities (COVID-19 closeness) of nodes that were visited by the RWR algorithm starting from nodes belonging to the COVID-19 module. Diseases that are high outliers and upper whiskers are highlighted in the figure.