TABLE 1.
Broth microdilution of released FLZ over a 7-day incubation period
| Species | Strain | FLZ-loaded CS eluent concn (μg/ml)a |
||||||
|---|---|---|---|---|---|---|---|---|
| Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | ||
| Candida albicans | SC5314 | 5 | 2.5 | 2.5 | 2.5 | 2.5 | 5 | 5 |
| ATCC 10231 | 1.2 | 0.3 | 0.6 | 0.3 | 0.6 | 1.2 | 0.6 | |
| Candida glabrata | ATCC 2001 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Candida auris | NCPF 8978 | 80 | 40 | 40 | 40 | 80 | 80 | 80 |
| NCPF 8973 | 20 | 20 | 20 | 80 | 80 | 80 | 80 | |
| Malessezia furfur | NCPF 3349 | |||||||
| Candida tropicalis | BC064 | >160 | >160 | >160 | >160 | >160 | >160 | >160 |
| Candida parapsilosis | NCPF 8334 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 1.2 | 2.5 |
| Candida haemolunii | DSM 70624 | 5 | 10 | 10 | 10 | 2.5 | 5 | 5 |
| Trichosporon spp. | 40 | 20 | 40 | 20 | 10 | 10 | 20 | |
| Rhodotorula spp. | >160 | >160 | >160 | >160 | >160 | >160 | >160 | |
| Aspergillus fumigatus | NCPF 7367 | >160 | >160 | >160 | >160 | >160 | >160 | >160 |
| Aspergillus brasiliensis | ATCC 16404 | >160 | >160 | >160 | >160 | >160 | >160 | >160 |
| Rhizopus spp. | ||||||||
| Scedosporium spp. | ||||||||
a
The table is representative of concentration dilutions extracted from 5 ml of approximately 160 μg/ml eluent of FLZ-loaded Stimulan Rapid Cure beads, diluted 1:1 across a plate with concentrations ranging from 160 to 0.3 μg/ml. Note that there was no inhibition for Malessezia furfur, Rhizopus spp., or Scedosporium spp.