TABLE 2.
Broth microdilution of released AMB over a 7-day incubation period
| Species | Strain | AMB-loaded CS eluent concn (μg/ml)a |
||||||
|---|---|---|---|---|---|---|---|---|
| Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | ||
| Candida albicans | SC5314 | 0.9 | 1.8 | <0.23 | 0.45 | 0.45 | 0.45 | 0.9 |
| ATCC 10231 | 0.9 | 0.9 | <0.23 | 0.9 | 0.45 | 0.45 | 0.9 | |
| Candida glabrata | ATCC 2001 | 1.8 | 0.9 | 0.45 | 0.45 | 0.45 | 0.45 | 1.8 |
| Candida auris | NCPF 8978 | 0.9 | 0.9 | 0.9 | 0.9 | 0.9 | 0.9 | 0.9 |
| NCPF 8973 | 0.9 | 0.9 | 0.9 | 0.9 | 1.8 | 0.9 | 0.9 | |
| Malessezia furfur | NCPF 3349 | 1.8 | 1.8 | 0.45 | 1.8 | 1.8 | 1.8 | 0.9 |
| Candida tropicalis | BC064 | 3.6 | 0.45 | 0.45 | 0.45 | 0.45 | 0.45 | <0.23 |
| Candida parapsilosis | NCPF 8334 | 1.8 | 0.9 | 0.9 | 0.9 | 0.45 | 0.45 | 0.45 |
| Candida haemolunii | DSM 70624 | 7 | 3.6 | 7 | 7 | 3.6 | 3.6 | 3.6 |
| Trichosporon spp. | <0.23 | <0.23 | <0.23 | <0.23 | <0.23 | <0.23 | <0.23 | |
| Rhodotorula spp. | 3.6 | 0.9 | 0.9 | 0.9 | 0.45 | 0.45 | 0.45 | |
| Aspergillus fumigatus | NCPF 7367 | 14 | 14 | 14 | 14 | 14 | 7 | 7 |
| Aspergillus brasiliensis | ATCC 16404 | 7 | 7 | 7 | 7 | 7 | 7 | 7 |
| Rhizopus spp. | 1.8 | 3.6 | 3.6 | 3.6 | 1.8 | 1.8 | 1.8 | |
| Scedosporium spp. | ||||||||
a
The table is representative of concentration dilutions extracted from 5 ml of approximately 114 μg/ml eluent of amphotericin B (AMB)-inoculated Stimulan Rapid Cure beads, diluted 1:1 across a plate with concentrations ranging from 114 to 0.23 μg/ml. Note that there was no inhibition for Scedosporium spp.