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. 2021 May 18;65(6):e00184-21. doi: 10.1128/AAC.00184-21

FIG 6.

FIG 6

Carbapenem complexes of OXA-48. (Top left) Imipenem acyl-enzyme (PDB ID 6P97) (46); interactions with active site residues are highlighted. The imipenem pyrroline ring is modeled as the Δ2 tautomer. (Top middle) Imipenem acyl-enzyme (PDB ID 6PTU) (47), with the pyrroline ring as the (R)-Δ1 tautomer. (Top right) Hydrolyzed imipenem (PDB ID 6PK0) (47), with the pyrroline ring as the (S)-Δ1 tautomer. (Bottom left) Doripenem acyl-enzyme (PDB ID 6P9C) (46), with the pyrroline ring as the Δ2 tautomer. (Bottom right) Doripenem acyl-enzyme (PDB ID 6PXX) (48), with the pyrroline ring as the (R)-Δ1 tautomer.