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Probability of target attainment (100% fT>MIC) for cefepime loading dose followed by extended and continuous infusion within the first 24 h. Dashed lines indicate 90% probability of target attainment. The mean (SD) weight used for the simulations was 119 kg (27 kg). Total effluent flow rate, blood flow rate, and CRRT downtime were fixed at 30 ml/kg/h, 300 ml/min, and 0 h, respectively. LD, loading dose.
