TABLE 2.

Population parameter estimates for cefepime final model^a

Parameter (unit)	Median	95% credibility interval	Mean	SD	CV (%)	Shrinkage (%)
kel (h−1)	0.07	0.04–0.09	0.07	0.05	71.73	0.31
kcp (h−1)	0.75	0.13–1.64	0.83	0.64	76.80	4.80
kpc (h−1)	3.23	0.25–5.00	2.47	2.25	90.94	1.50
Vcentral (liters)	18.67	9.18–45.02	26.76	15.09	56.37	1.44
VCRRT (liters)	2.09	0.01–3.47	1.98	1.69	85.41	3.27
Veffluent (liters)	0.18	8 × 10−4–0.85	0.57	0.66	116.25	3.72
Vpostdialyzer (liters)	1.28	0.81–3.38	1.79	1.34	74.90	10.75

^aCRRT, continuous renal replacement therapy compartment; CV, coefficient of variation; k_cp, rate of transfer from the central to the peripheral compartment; k_el, elimination rate constant; k_pc, rate of transfer from the peripheral to the central compartment; SD, standard deviation; V, volume of distribution.