TABLE 1.
Top 10 proteins which were found to have significant changes in abundance at 2 and 8 mg · liter−1 itraconazole
| Itraconazole concn (mg liter−1) | Upregulated |
Downregulated |
||||||
|---|---|---|---|---|---|---|---|---|
| P value | Difference | Protein ID | Protein name or description | P value | Difference | Protein IDs | Protein name or description | |
| 2 | 3.8E−05 | 6.68 | A0A117E0T6 | Sterol 24-C-methyltransferase | 0.0025 | −5.19 | XP_001389347.1 | Isocitrate lyase |
| 5.9E−07 | 5.41 | A0A117DW86 | ABC transporter | 0.0011 | −3.94 | A0A100IR47 | Oxaloacetate acetylhydrolase | |
| 1.8E−05 | 4.02 | XP_025478936.1 | Glutathione peroxidase Hyr1 | 0.0004 | −3.52 | A0A100IPP9 | Geranylgeranyl pyrophosphate synthase | |
| 1.7E−03 | 3.16 | A0A117E2H8 | Choline oxidase | 0.0000 | −3.19 | A0A100IHE1 | Glycerol-3-phosphate dehydrogenase | |
| 2.1E−02 | 2.85 | A0A100IEW1 | F5/8 type C domain protein | 0.0010 | −3.05 | A0A124BYU7 | Allergen | |
| 4.4E−03 | 2.72 | G3Y367 | Protein disulfide-isomerase | 0.0087 | −3.03 | XP_025476110.1 | Hypothetical protein BO87DRAFT_379724 | |
| 4.0E−04 | 2.03 | A0A100IRZ3 | Protein disulfide-isomerase | 0.0067 | −2.90 | A0A124BY46 | Pathogenesis-associated protein Cap20 | |
| 1.1E−03 | 2.02 | XP_001391010.1 | Hit family protein 1 | 0.0089 | −2.54 | A0A117DVZ9 | Catalase | |
| 1.1E−03 | 1.79 | G3XSV7 | Uncharacterized protein | 0.0202 | −2.38 | A0A100I3Y8 | Aldehyde dehydrogenase | |
| 1.6E−03 | 1.68 | A0A100I439 | Translationally controlled tumor protein homolog | 0.0077 | −2.30 | A0A100IQA9 | Alcohol dehydrogenase (adhA) | |
| 8 | 4.2E−05 | 6.40 | A0A117E0T6 | Sterol 24-C-methyltransferase | 0.0019 | −5.92 | XP_001389347.1 | Isocitrate lyase |
| 3.1E−06 | 5.04 | A0A117DW86 | ABC transporter | 0.0058 | −4.81 | XP_025485096.1 | Superoxide dismutase [Mn], mitochondrial | |
| 1.1E−02 | 3.70 | A0A100IIZ2 | Cyp51A | 0.0006 | −4.41 | A0A100IR47 | Oxaloacetate acetylhydrolase | |
| 1.0E−04 | 3.61 | XP_025478936.1 | Glutathione peroxidase Hyr1 | 0.0029 | −3.36 | A0A100IPP9 | Geranylgeranyl pyrophosphate synthase | |
| 9.0E−03 | 2.81 | A0A100I6D1 | FAD-binding PCMH-type domain-containing protein | 0.0015 | −2.36 | A0A124BYU7 | Allergen | |
| 1.5E−04 | 1.86 | A0A100IA04 | Aspartic protease PEPAd | 0.0100 | −2.31 | A0A117DVZ9 | Catalase | |
| 7.0E−03 | 1.74 | XP_001391010.1 | Hit family protein 1 | 0.0001 | −2.30 | A0A100IHE1 | Glycerol-3-phosphate dehydrogenase | |
| 6.9E−03 | 1.40 | XP_001395889.1 | Actin-related protein 2/3 complex subunit ARC19 | 0.0001 | −2.23 | A0A100IKP3 | Peroxisomal multifunctional beta-oxidation protein | |
| 5.2E−03 | 1.38 | G3XS64 | ATP synthase subunit delta, mitochondrial | 0.0060 | −2.18 | XP_025476110.1 | Hypothetical protein BO87DRAFT_379724 | |
| 1.5E−03 | 1.37 | A0A100II93 | N,N-dimethylglycine oxidase | 0.0052 | −2.10 | G3XT80 | Thioredoxin reductase | |