FIG 6.

Cross-reactivity of ZIKV and homologous flavivirus peptides. Three short-term TCLs were generated based on epitope/donor combinations that generated high-magnitude responses in the primary screen. Following a 14-day in vitro expansion, TCLs were tested by FluoroSpot assay for reactivity to the original ZIKV peptide used for expansion as well as homologous peptides from DENV and other flaviviruses where cell numbers permitted. Keys below the graphs indicate the sequences of peptides used for analysis as well as the percent sequence identity of each peptide to ZIKV.