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HFIM experiment in which a stably derepressed Pseudomonas aeruginosa PA01 isolate was exposed to six different AVI exposures by intermittent administration every 8 h. These were intended to produce times with AVI concentrations of ≥4 mg/liter of 4 of 8 h through 8 of 8 h. A no-treatment control was included. In all treatment arms, a CAZ exposure profile simulating 2 g IV every 8 h as a 2-h infusion was employed. CI, continuous infusion.
